文档预览： INTRODUCTION The inhibitor of apoptosis protein (IAP) family comprises a class of cell death inhibitors containing one to three BIR (baculovirus IAP repeat) domains (Deveraux and Reed, 1999). They were initially identified as baculoviral proteins that prevent the host cell from undergoing apoptosis following ... 点击下载

文档预览： n e w s nature medicine volume 18 | number 1 | january 2012 7 Next-generation proteasome blockers promise safer cancer therapy As recently as a decade ago, ... 点击下载

文档预览： Some lines of evidence support the concept that altered expression of subsets of ...all eukaryotes from yeast to human and existing in several cellular ... 点击下载

文档预览： Lactacystin Product Number L 6785 Storage Temperature -20 C Product Description Molecular Formula: C 15 H 24 N 2 O 7 S Molecular Weight: 376.4 CAS Number: 133343-34-7 Lactacystin is a Streptomyces metabolite that was found in the ... 点击下载

文档预览： The Ubiquitin-Proteasome Pathwayand Proteasome InhibitorsJayhyuk Myung,1Kyung Bo Kim,1Craig M. Crews1,21Department of Molecular, Cellular, and Developmental... 点击下载

文档预览： Even some neuropathies with a known inherited pathogenesis (e.g. the ...Overall, I think that the book is a useful read for all24 I ACNR ... 点击下载

文档预览： Kenny K.K. Chung, Valina L. Dawson and Ted M. Dawson* Dept of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. *e-mail: tdawson@jhmi.edu http://trends.com S7 TINS Vol.24 No.11 (Suppl.) November 2001 A ... 点击下载

文档预览： proteasome-mediated degradation pro-cesses (e.g. deubiquitination). Here, we discuss howthese ndings support a central role for CSN in ubiquiti-nation of substr 点击下载

文档预览： Two types of subunits (25 kDa): αand β, all differ .Subunits are ...proteinubiquitinationproteasomeODCc-Junc-FoscalpailysosomalIII. Protein ... 点击下载

文档预览： National institutes of Health Office of Technology Transfer Page 1 of 2 September 2003 R&D TIMELINE Myogenetics creates proteasome inhibitors (PI) mid 1990s Myogenetics explored disease applications for PIs 1994-1996 MG-341 (Velcade Precursor) ... 点击下载