Chapter 4: Cell Membrane and Cell Surface
I. Cell Membrane
II. Cell Junctions
III. Cell Adhesion
IV. Extracellular Matrix
http://www.cbi.pku.edu.cn/chinese/documents/chenjg/

I. Biomembranes: Their Structure, Chemistry and Functions
Learning objectives:
A brief history of studies on the structrure of the plasma membrane
Model of membrane structure: an experimental perspective
The chemical composition of membranes
Characteristics of biomembrane
An overview of the functions of biomembranes
1. A brief history of studies
on the structrure of the
plasmic membrane
A. Conception:
Plasma membrane(cell membrane),
Intracellular membrane,
Biomembrane.
B. The history of study
Overton(1890s):
Lipid nature of PM;
J.D.Robertson(1959):
The TEM showing:the trilaminar appearance of PM;
Unit membrane model;
S.J.Singer and G.Nicolson(1972):
fluid-mosaic model;
K.Simons et al(1997):
lipid rafts model;
Functional rafts in Cell
membranes.
Nature 387:569-572

2. Singer and Nicolson's Model of membrane structure: The fluid-mosaic model is the "central dogma" of membrane biology.
The core lipid bilayer exists in a fluid state, capable of dynamic movement.
Membrane proteins form a mosaic of particles penetrating the lipid to varying degrees.
The Fluid Mosaic Model, proposed in 1972 by Singer and Nicolson, had two key features, both implied in its name.
3. The chemical composition of membranes
A. Membrane Lipids: The Fluid Part of the Model

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