盐酸万乃洛韦抑制疗法预防生殖器疱疹
复发的观察
刘恩让,陈冰,谢倩,张书岭
[摘 要] 目的 观察复发性生殖器疱疹患者应用盐酸万乃洛韦抑制疗法期间疱疹的复发情况.方法 选择频发
性生殖器疱疹患者(平均每年发作6次以上),应用盐酸万乃洛韦300 mg ,2次/ d ,至皮损消失,临床痊愈.盐酸万乃洛韦
抑制疗法:开始剂量为300 mg ,1次/ d ,连服4周,然后减量为盐酸万乃洛韦300 mg ,隔日1次,连服1年.结果 符合观
察标准的46例,连续使用盐酸万乃洛韦3个月的无复发率为86. 96 %(40/ 46).在第2,第3和第4个3个月中,无复发率
分别为80. 43 %(37/ 46),84. 78 %(39/ 46),82. 61 %(38/ 46),1年的无复发率为71. 74 %(33/ 46).结论 盐酸万乃洛韦持
续抑制疗法能很好地预防生殖器疱疹复发.
[关键词] 生殖器疱疹;盐酸万乃洛韦
[中图分类号] R 752. 1 [文献标识码] A [文章编号] 1001 - 7089(2004)01 - 0021 - 02
The Observation of Valacyclovir Hydrochloride Suppression f or Preventing Relapse of Genital Herpes
L IU En2rang ,CHEN Bin ,XIE Qian ,etal
(T heDepart mentofDerm atology,T heSecon dPeopleHospit alofS henz henCity,S henz hen510835,Chi na)
Abstract : Objective To investigate relapse rate of recurrentgenital herpes in t he stage of valacyclovir hydrochloride
lizhuwei suppression t herapy.Methods Thepatients wit h recurrentgenital herpes were dosed lizhuwei 300 mg Bid. after herpes
resolution and clinic cure ,t hepatients continued to take lizhuwei 300 mg once a day for 4 weeks. and t hen ,t he dose of lizhuwei
were decreased to 300 mg once two days for more t han oneyear.Results 46patients wit hgenital herpes were observed ,t here is
a unrelapse rate of 86. 96 %and 71. 74 % respectively in continued dosing of 3 mont hs and oneyear. and also t here is a unrelapse
rate of 80. 43 % ,84. 78 %and 82. 61 % respectively in t he second ,t he t hird and t he fourt h t hree mont hs of continued dosing.Con2
clusion Lizhuwei suppression t herapy have high effect inpreventing relapse ofgenital herpes.
Key words : Genital herpes ;Valacyclovir hydrochloride
盐酸万乃洛韦是阿昔洛韦的左旋缬氨酸酯,其治
疗生殖器疱疹的疗效和安全性已得到普遍认可,并已
广泛用于临床治疗.将盐酸万乃洛韦用于预防生殖器
疱疹的复发国外已有不少报道[ 1～4 ].2001年4月～
2002年12月,我们应用盐酸万乃洛韦(商品名:丽珠
威,由广东丽珠制药厂生产,下称丽珠威)持续抑制疗
法(下称:抑制疗法)对46例复发性生殖器疱疹患者进
行治疗,观察持续应用抑制疗法期间疱疹的无复发率

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